As a comment to the Rotman Management design issue (pdf) magazine Victor Lombardi quotes Jeanne Liedtka from page 12:
The most fundamental difference between the two, they argue, is that design thinking deals primarily with what does not yet exist; while scientists deal with explaining what is. That scientists discover the laws that govern today’s reality, while designers invent a different future is a common theme. Thus, while both methods of thinking are hypothesis-driven, the design hypothesis differs from the scientific hypothesis.
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